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Title:

Elevated systemic levels of the matrix metalloproteinase inhibitor TIMP-1 correlate with clinical markers of cachexia in patients with chronic pancreatitis and pancreatic cancer.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Prokopchuk, Olga; Grünwald, Barbara; Nitsche, Ulrich; Jäger, Carsten; Prokopchuk, Oleksii L; Schubert, Elaine C; Friess, Helmut; Martignoni, Marc E; Krüger, Achim
Abstract:
BACKGROUND: Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a candidate diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma (PDAC). Here, we determined the possible association of systemic TIMP-1 levels with cachexia and jaundice, two common PDAC-associated conditions. METHODS: Plasma TIMP-1 was measured by ELISA in patients diagnosed with PDAC (n = 36) and chronic pancreatitis (CP) (n = 25). Patients without pancreatic pathologies and known malignancies of other origin...     »
Journal title abbreviation:
BMC Cancer
Year:
2018
Journal volume:
18
Journal issue:
1
Fulltext / DOI:
doi:10.1186/s12885-018-4055-9
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29394913
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Experimentelle Onkologie und Therapieforschung
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