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Title:

Exploring Cytotoxic mRNAs as a Novel Class of Anti-cancer Biotherapeutics.

Document type:
Article; Journal Article
Author(s):
Hirschberger, Kristin; Jarzebinska, Anita; Kessel, Eva; Kretzschmann, Verena; Aneja, Manish K; Dohmen, Christian; Herrmann-Janson, Annika; Wagner, Ernst; Plank, Christian; Rudolph, Carsten
Abstract:
New treatments to overcome the obstacles of conventional anti-cancer therapy are a permanent subject of investigation. One promising approach is the application of toxins linked to cell-specific ligands, so-called immunotoxins. Another attractive option is the employment of toxin-encoding plasmids. However, immunotoxins cause hepatoxicity, and DNA therapeutics, among other disadvantages, bear the risk of insertional mutagenesis. As an alternative, this study examined chemically modified mRNAs co...     »
Journal title abbreviation:
Mol Ther Methods Clin Dev
Year:
2018
Journal volume:
8
Pages contribution:
141-151
Fulltext / DOI:
doi:10.1016/j.omtm.2017.12.006
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29687033
Print-ISSN:
2329-0501
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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