Comparison of contact radiographed and stained histological sections for osseointegration analysis of dental implants: an in vivo study.

Bissinger, Oliver; Götz, Carolin; Jeschke, Anke; Haller, Bernhard; Wolff, Klaus-Dietrich; Kaiser, Pascal; Kolk, Andreas

doi:10.1016/j.oooo.2017.06.118

2018

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Dokumenttyp:: Comparative Study; Journal Article
Autor(en):: Bissinger, Oliver; Götz, Carolin; Jeschke, Anke; Haller, Bernhard; Wolff, Klaus-Dietrich; Kaiser, Pascal; Kolk, Andreas
Titel:: Comparison of contact radiographed and stained histological sections for osseointegration analysis of dental implants: an in vivo study.
Abstract:: OBJECTIVES: Histology is still regarded as the gold-standard to determine bone implant contact (BIC) as a parameter representing implant stability. As the further processing of cut slices for contact radiography (CR) to stained and polished histological sections is time consuming and error prone, our aim was to assess agreement between CR and Giemsa-eosin (GE) stained sections with regard to dental implants. STUDY DESIGN: Threaded dental titanium implants (n = 54) from the maxillae of Goettingen minipigs were evaluated. After 28 and 56 days, BIC and the ratio of bone volume to total volume (BV/TV; 1000 μm) were determined on the same sections by using CR and GE staining, and the results were compared. RESULTS: Moderate differences for BIC (0.6%; P = .53) and BV/TV (1.3%; P = .01) between the methods were determined, in which CR overestimated BIC and BV/TV. A strong correlation was seen between the modalities concerning BIC (28 days: r = 0.84; 56 days: r = 0.85; total: r = 0.85) and BV/TV (r = 0.96; r = 0.94; r = 0.96; all: P < .0001). CONCLUSIONS: CR enabled determination of the bone-to-implant interface in comparison with GE-stained sections. BIC and BV/TV were slightly overestimated but correlated strongly between the methods. Therefore, if BIC and BV/TV are sufficient endpoints, CR is adequate and no further preparation and staining are necessary.
Zeitschriftentitel:: Oral Surg Oral Med Oral Pathol Oral Radiol
Jahr:: 2018
Band / Volume:: 125
Heft / Issue:: 1
Seitenangaben Beitrag:: 20-26
Volltext / DOI:: doi:10.1016/j.oooo.2017.06.118
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/29079369
Print-ISSN:: 2212-4403
TUM Einrichtung:: Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
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