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Titel:

Type I Immune Response Induces Keratinocyte Necroptosis and Is Associated with Interface Dermatitis.

Dokumenttyp:
Journal Article
Autor(en):
Lauffer, Felix; Jargosch, Manja; Krause, Linda; Garzorz-Stark, Natalie; Franz, Regina; Roenneberg, Sophie; Böhner, Alexander; Mueller, Nikola S; Theis, Fabian J; Schmidt-Weber, Carsten B; Biedermann, Tilo; Eyerich, Stefanie; Eyerich, Kilian
Abstract:
Interface dermatitis is a characteristic histological pattern that occurs in autoimmune and chronic inflammatory skin diseases. It is unknown whether a common mechanism orchestrates this distinct type of skin inflammation. Here we investigated the overlap of two different interface dermatitis positive skin diseases, lichen planus and lupus erythematosus. The shared transcriptome signature pointed toward a strong type I immune response, and biopsy-derived T cells were dominated by IFN-? and tumor...     »
Zeitschriftentitel:
J Invest Dermatol
Jahr:
2018
Band / Volume:
138
Heft / Issue:
8
Seitenangaben Beitrag:
1785-1794
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jid.2018.02.034
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29526761
Print-ISSN:
0022-202X
TUM Einrichtung:
Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber); Professur für Experimentelle Dermato-Immunologie (Prof. Eyerich)
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