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Document type:
Journal Article 
Author(s):
Weidenbusch, Bushra; Richter, Günther H S; Kesper, Marie Sophie; Guggemoos, Monika; Gall, Katja; Prexler, Carolin; Kazantsev, Ilya; Sipol, Alexandra; Lindner, Lars; Nathrath, Michaela; Witt, Olaf; Specht, Katja; Beitinger, Frigga; Knebel, Carolin; Hosie, Stuart; von Eisenhardt-Rothe, Rüdiger; Weichert, Wilko; Luettichau, Irene Teichert-von; Burdach, Stefan 
Title:
Transcriptome based individualized therapy of refractory pediatric sarcomas: feasibility, tolerability and efficacy. 
Abstract:
Survival rates of pediatric sarcoma patients stagnated during the last two decades, especially in adolescents and young adults (AYAs). Targeted therapies offer new options in refractory cases. Gene expression profiling provides a robust method to characterize the transcriptome of each patient's tumor and guide the choice of therapy. Twenty patients with refractory pediatric sarcomas (age 8-35 years) were assessed with array profiling: ten had Ewing sarcoma, five osteosarcoma, and five soft tissu...    »
 
Journal title abbreviation:
Oncotarget 
Year:
2018 
Journal volume:
Journal issue:
29 
Pages contribution:
20747-20760 
Language:
eng 
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin; Klinik und Poliklinik für Orthopädie und Sportorthopädie