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Title:

Transcriptome based individualized therapy of refractory pediatric sarcomas: feasibility, tolerability and efficacy.

Document type:
Journal Article
Author(s):
Weidenbusch, Bushra; Richter, Günther H S; Kesper, Marie Sophie; Guggemoos, Monika; Gall, Katja; Prexler, Carolin; Kazantsev, Ilya; Sipol, Alexandra; Lindner, Lars; Nathrath, Michaela; Witt, Olaf; Specht, Katja; Beitinger, Frigga; Knebel, Carolin; Hosie, Stuart; von Eisenhardt-Rothe, Rüdiger; Weichert, Wilko; Luettichau, Irene Teichert-von; Burdach, Stefan
Abstract:
Survival rates of pediatric sarcoma patients stagnated during the last two decades, especially in adolescents and young adults (AYAs). Targeted therapies offer new options in refractory cases. Gene expression profiling provides a robust method to characterize the transcriptome of each patient's tumor and guide the choice of therapy. Twenty patients with refractory pediatric sarcomas (age 8-35 years) were assessed with array profiling: ten had Ewing sarcoma, five osteosarcoma, and five soft tissu...     »
Journal title abbreviation:
Oncotarget
Year:
2018
Journal volume:
9
Journal issue:
29
Pages contribution:
20747-20760
Language:
eng
Fulltext / DOI:
doi:10.18632/oncotarget.25087
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29755686
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin; Klinik und Poliklinik für Orthopädie und Sportorthopädie
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