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Title:

Donor lymphocyte infusions in adolescents and young adults for control of advanced pediatric sarcoma.

Document type:
Journal Article
Author(s):
Schober, Sebastian J; von Luettichau, Irene; Wawer, Angela; Steinhauser, Maximilian; Salat, Christoph; Schwinger, Wolfgang; Ussowicz, Marek; Antunovic, Petar; Castagna, Luca; Kolb, Hans-Jochem; Burdach, Stefan E G; Thiel, Uwe
Abstract:
Background: Allogeneic stem cell transplantation (allo-SCT) and donor lymphocyte infusions (DLI) may induce a graft-versus-tumor effect in pediatric sarcoma patients. Here, we describe general feasibility, toxicity and efficacy of DLI after allo-SCT. Results: 4 of 8 patients responded. ES#4 had stable disease (SD) for 9 months after DLI and RMS#4 partial response for 8 months with combined hyperthermia/chemotherapy. In ES#4, DLI led to SD for 6 months and reverted residual disease before allo-SC...     »
Journal title abbreviation:
Oncotarget
Year:
2018
Journal volume:
9
Journal issue:
32
Pages contribution:
22741-22748
Fulltext / DOI:
doi:10.18632/oncotarget.25228
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29854312
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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