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Titel:

Human T cells modulate myeloid-derived suppressor cells through a TNF-?-mediated mechanism.

Dokumenttyp:
Journal Article; Article
Autor(en):
Bauswein, Markus; Singh, Anurag; Ralhan, Anjali; Neri, Davide; Fuchs, Katharina; Blanz, Kelly Daryll; Schäfer, Iris; Hector, Andreas; Handgretinger, Rupert; Hartl, Dominik; Rieber, Nikolaus
Abstract:
Myeloid-derived suppressor cells (MDSC) represent an innate immune cell subset capable of suppressing T-cell responses in cancer and chronic inflammation. While the effect of MDSC on T cells has been defined thoroughly, the reciprocal impact of T cells on MDSC homeostasis remains poorly understood. Therefore, we comprehensively analyzed the effect of different T-cell subsets on the generation and survival of human MDSC. Using an in vitro MDSC generation assay, we demonstrate that unstimulated CD...     »
Zeitschriftentitel:
Immunol Lett
Jahr:
2018
Band / Volume:
202
Seitenangaben Beitrag:
31-37
Volltext / DOI:
doi:10.1016/j.imlet.2018.07.010
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30076856
Print-ISSN:
0165-2478
TUM Einrichtung:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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