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Titel:

Epstein-Barr virus strain heterogeneity impairs human T-cell immunity.

Dokumenttyp:
Journal Article
Autor(en):
Cirac, Ana; Stützle, Simon; Dieckmeyer, Michael; Adhikary, Dinesh; Moosmann, Andreas; Körber, Nina; Bauer, Tanja; Witter, Klaus; Delecluse, Henri-Jacques; Behrends, Uta; Mautner, Josef
Abstract:
The Epstein-Barr virus (EBV) establishes lifelong infections in > 90% of the human population. Although contained as asymptomatic infection by the immune system in most individuals, EBV is associated with the pathogenesis of approximately 1.5% of all cancers in humans. Some of these EBV-associated tumors have been successfully treated by the infusion of virus-specific T-cell lines. Recent sequence analyses of a large number of viral isolates suggested that distinct EBV strains have evolved in di...     »
Zeitschriftentitel:
Cancer Immunol Immunother
Jahr:
2018
Band / Volume:
67
Heft / Issue:
4
Seitenangaben Beitrag:
663-674
Volltext / DOI:
doi:10.1007/s00262-018-2118-z
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29374782
Print-ISSN:
0340-7004
TUM Einrichtung:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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