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Title:

Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.

Document type:
Journal Article
Author(s):
Rosendahl, Jonas; Kirsten, Holger; Hegyi, Eszter; Kovacs, Peter; Weiss, Frank Ulrich; Laumen, Helmut; Lichtner, Peter; Ruffert, Claudia; Chen, Jian-Min; Masson, Emmanuelle; Beer, Sebastian; Zimmer, Constantin; Seltsam, Katharina; Algül, Hana; Bühler, Florence; Bruno, Marco J; Bugert, Peter; Burkhardt, Ralph; Cavestro, Giulia Martina; Cichoz-Lach, Halina; Farré, Antoni; Frank, Josef; Gambaro, Giovanni; Gimpfl, Sebastian; Grallert, Harald; Griesmann, Heidi; Grützmann, Robert; Hellerbrand, Claus; H...     »
Abstract:
OBJECTIVE: Alcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-wide association study and functional characterisation of a new pancreatitis locus. DESIGN: 1959 European alcoholic CP patients and...     »
Journal title abbreviation:
Gut
Year:
2018
Journal volume:
67
Journal issue:
10
Pages contribution:
1855-1863
Language:
eng
Fulltext / DOI:
doi:10.1136/gutjnl-2017-314454
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28754779
Print-ISSN:
0017-5749
TUM Institution:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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