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Titel:

Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.

Dokumenttyp:
Journal Article
Autor(en):
Rosendahl, Jonas; Kirsten, Holger; Hegyi, Eszter; Kovacs, Peter; Weiss, Frank Ulrich; Laumen, Helmut; Lichtner, Peter; Ruffert, Claudia; Chen, Jian-Min; Masson, Emmanuelle; Beer, Sebastian; Zimmer, Constantin; Seltsam, Katharina; Algül, Hana; Bühler, Florence; Bruno, Marco J; Bugert, Peter; Burkhardt, Ralph; Cavestro, Giulia Martina; Cichoz-Lach, Halina; Farré, Antoni; Frank, Josef; Gambaro, Giovanni; Gimpfl, Sebastian; Grallert, Harald; Griesmann, Heidi; Grützmann, Robert; Hellerbrand, Claus; H...     »
Abstract:
OBJECTIVE: Alcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-wide association study and functional characterisation of a new pancreatitis locus. DESIGN: 1959 European alcoholic CP patients and...     »
Zeitschriftentitel:
Gut
Jahr:
2018
Band / Volume:
67
Heft / Issue:
10
Seitenangaben Beitrag:
1855-1863
Sprache:
eng
Volltext / DOI:
doi:10.1136/gutjnl-2017-314454
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28754779
Print-ISSN:
0017-5749
TUM Einrichtung:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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