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Titel:

Identification of essential amino acids for glucose transporter 5 (GLUT5)-mediated fructose transport.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Ebert, Karolin; Ewers, Maren; Bisha, Ina; Sander, Simone; Rasputniac, Tanja; Daniel, Hannelore; Antes, Iris; Witt, Heiko
Abstract:
Intestinal fructose uptake is mainly mediated by glucose transporter 5 (GLUT5/SLC2A5). Its closest relative, GLUT7, is also expressed in the intestine but does not transport fructose. For rat Glut5, a change of glutamine to glutamic acid at codon 166 (p.Q166E) has been reported to alter the substrate-binding specificity by shifting Glut5-mediated transport from fructose to glucose. Using chimeric proteins of GLUT5 and GLUT7, here we identified amino acid residues of GLUT5 that define its substra...     »
Zeitschriftentitel:
J Biol Chem
Jahr:
2018
Band / Volume:
293
Heft / Issue:
6
Seitenangaben Beitrag:
2115-2124
Volltext / DOI:
doi:10.1074/jbc.RA117.001442
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29259131
Print-ISSN:
0021-9258
TUM Einrichtung:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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