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Titel:

The endochondral bone protein CHM1 sustains an undifferentiated, invasive phenotype, promoting lung metastasis in Ewing sarcoma.

Dokumenttyp:
Journal Article; Article
Autor(en):
von Heyking, Kristina; Calzada-Wack, Julia; Göllner, Stefanie; Neff, Frauke; Schmidt, Oxana; Hensel, Tim; Schirmer, David; Fasan, Annette; Esposito, Irene; Müller-Tidow, Carsten; Sorensen, Poul H; Burdach, Stefan; Richter, Günther H S
Abstract:
Ewing sarcomas (ES) are highly malignant, osteolytic bone or soft tissue tumors, which are characterized by EWS-ETS translocations and early metastasis to lung and bone. In this study, we investigated the role of the BRICHOS chaperone domain-containing endochondral bone protein chondromodulin I (CHM1) in ES pathogenesis. CHM1 is significantly overexpressed in ES, and chromosome immunoprecipitation (ChIP) data demonstrate CHM1 to be directly bound by an EWS-ETS translocation, EWS-FLI1. Using RNA...     »
Zeitschriftentitel:
Mol Oncol
Jahr:
2017
Band / Volume:
11
Heft / Issue:
9
Seitenangaben Beitrag:
1288-1301
Sprache:
eng
Volltext / DOI:
doi:10.1002/1878-0261.12057
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28319320
Print-ISSN:
1574-7891
TUM Einrichtung:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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