The current controversial discussion on disease-specific survival of patients with HPV+ and HPV- HNSCC was motivation for the present meta-analysis. A literature search was performed via PubMed/NCBI, and data extraction and statistical analysis were conducted. A total of 139 studies published between 2004 and 2014 were evaluated in the meta-analysis. The evaluation demonstrated that the survival rates reported in numerous studies were not evaluated multifactorially and important confounders were excluded from the statistics. The considerations of a tailored therapy according to HPV status should be viewed critically based on the present information.
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The current controversial discussion on disease-specific survival of patients with HPV+ and HPV- HNSCC was motivation for the present meta-analysis. A literature search was performed via PubMed/NCBI, and data extraction and statistical analysis were conducted. A total of 139 studies published between 2004 and 2014 were evaluated in the meta-analysis. The evaluation demonstrated that the survival rates reported in numerous studies were not evaluated multifactorially and important confounders were...
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