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Document type:
Journal Article 
Author(s):
Spanopoulou, Anna; Heidrich, Luzia; Chen, Hong-Ru; Frost, Christina; Hrle, Dean; Malideli, Eleni; Hille, Kathleen; Grammatikopoulos, Alexandros; Bernhagen, Jürgen; Zacharias, Martin; Rammes, Gerhard; Kapurniotu, Aphrodite 
Title:
Designed Macrocyclic Peptides as Nanomolar Amyloid Inhibitors Based on Minimal Recognition Elements. 
Abstract:
Amyloid self-assembly is linked to the pathogenesis of Alzheimer's disease (AD) and type 2 diabetes (T2D), but so far, no anti-amyloid compound has reached the clinic. Macrocyclic peptides belong to the most attractive drug candidates. Herein we present macrocyclic peptides (MCIPs) designed using minimal IAPP-derived recognition elements as a novel class of nanomolar amyloid inhibitors of both A?40(42) and IAPP or A?40(42) alone and show that chirality controls inhibitor selectivity. Sequence op...    »
 
Journal title abbreviation:
Angew Chem Int Ed Engl 
Year:
2018 
Journal volume:
57 
Journal issue:
44 
Pages contribution:
14503-14508 
Fulltext / DOI:
Print-ISSN:
1433-7851 
TUM Institution:
Klinik für Anästhesiologie (DHM)