Plasma levels of soluble amyloid precursor protein ? in symptomatic Alzheimer's disease.

Alexopoulos, Panagiotis; Gleixner, Lena-Sophie; Werle, Lukas; Buhl, Felix; Thierjung, Nathalie; Giourou, Evangelia; Kagerbauer, Simone M; Gourzis, Philippos; Kübler, Hubert; Grimmer, Timo; Yakushev, Igor; Martin, Jan; Kurz, Alexander; Perneczky, Robert

doi:10.1007/s00406-017-0815-9

2018

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Document type:: Journal Article
Author(s):: Alexopoulos, Panagiotis; Gleixner, Lena-Sophie; Werle, Lukas; Buhl, Felix; Thierjung, Nathalie; Giourou, Evangelia; Kagerbauer, Simone M; Gourzis, Philippos; Kübler, Hubert; Grimmer, Timo; Yakushev, Igor; Martin, Jan; Kurz, Alexander; Perneczky, Robert
Title:: Plasma levels of soluble amyloid precursor protein ? in symptomatic Alzheimer's disease.
Abstract:: The established biomarkers of Alzheimer's disease (AD) require invasive endeavours or presuppose sophisticated technical equipment. Consequently, new biomarkers are needed. Here, we report that plasma levels of soluble amyloid precursor protein ? (sAPP?), a protein of the initial phase of the amyloid cascade, were significantly lower in patients with symptomatic AD (21 with mild cognitive impairment due to AD and 44 with AD dementia) with AD-typical cerebral hypometabolic pattern compared with 27 cognitively healthy elderly individuals without preclinical AD. These findings yield further evidence for the potential of sAPP? in plasma as an AD biomarker candidate. «
The established biomarkers of Alzheimer's disease (AD) require invasive endeavours or presuppose sophisticated technical equipment. Consequently, new biomarkers are needed. Here, we report that plasma levels of soluble amyloid precursor protein ? (sAPP?), a protein of the initial phase of the amyloid cascade, were significantly lower in patients with symptomatic AD (21 with mild cognitive impairment due to AD and 44 with AD dementia) with AD-typical cerebral hypometabolic pattern compared with 2... »
Journal title abbreviation:: Eur Arch Psychiatry Clin Neurosci
Year:: 2018
Journal volume:: 268
Journal issue:: 5
Pages contribution:: 519-524
Language:: eng
Fulltext / DOI:: doi:10.1007/s00406-017-0815-9
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/28602012
Print-ISSN:: 0940-1334
TUM Institution:: Klinik für Anästhesiologie (DHM); Klinik und Poliklinik für Nuklearmedizin; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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