In this thesis, a patient-specific coupled electro-mechano-hemodynamic model is developed to investigate cardiac performance of human atria. The clinical importance of the model is demonstrated for the treatment of atrial fibrillation by evaluating different ablation strategies on patient-specific atria. The model's efficiency is improved by developing p-adaptive high-order Hybridizable Discontinuous Galerkin methods for electrophysiology. For model personalization, an automated, time-efficient process to define fiber orientations in arbitrarily shaped atria using registration and reorientation methods is introduced.
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In this thesis, a patient-specific coupled electro-mechano-hemodynamic model is developed to investigate cardiac performance of human atria. The clinical importance of the model is demonstrated for the treatment of atrial fibrillation by evaluating different ablation strategies on patient-specific atria. The model's efficiency is improved by developing p-adaptive high-order Hybridizable Discontinuous Galerkin methods for electrophysiology. For model personalization, an automated, time-efficient...
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