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Titel:

Neurofilament as a blood marker for diagnosis and monitoring of primary progressive aphasias.

Dokumenttyp:
Article; Journal Article
Autor(en):
Steinacker, Petra; Semler, Elisa; Anderl-Straub, Sarah; Diehl-Schmid, Janine; Schroeter, Matthias L; Uttner, Ingo; Foerstl, Hans; Landwehrmeyer, Bernhard; von Arnim, Christine A F; Kassubek, Jan; Oeckl, Patrick; Huppertz, Hans-Jürgen; Fassbender, Klaus; Fliessbach, Klaus; Prudlo, Johannes; Roßmeier, Carola; Kornhuber, Johannes; Schneider, Anja; Volk, Alexander E; Lauer, Martin; Danek, Adrian; Ludolph, Albert C; Otto, Markus
Abstract:
OBJECTIVE: To assess the utility of serum neurofilament for diagnosis and monitoring of primary progressive aphasia (PPA) variants. METHODS: We investigated neurofilament light chain (NF-L) levels in blood of 99 patients with PPA (40 with nonfluent variant PPA [nfvPPA], 38 with semantic variant PPA [svPPA], 21 with logopenic variant PPA [lvPPA]) and compared diagnostic performance with that reached by CSF NF-L, phosphorylated neurofilament heavy chain (pNF-H), β-amyloid (Aβ1-42), tau, and phosph...     »
Zeitschriftentitel:
Neurology
Jahr:
2017
Band / Volume:
88
Heft / Issue:
10
Seitenangaben Beitrag:
961-969
Sprache:
eng
Volltext / DOI:
doi:10.1212/WNL.0000000000003688
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28179468
Print-ISSN:
0028-3878
TUM Einrichtung:
Klinik und Poliklinik für Psychiatrie und Psychotherapie
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