Fluid biomarker agreement and interrelation in dementia due to Alzheimer's disease.

Alexopoulos, Panagiotis; Roesler, Jennifer; Werle, Lukas; Thierjung, Nathalie; Lentzari, Iliana; Ortner, Marion; Grimmer, Timo; Laskaris, Nikolaos; Politis, Antonios; Gourzis, Philippos; Kurz, Alexander; Perneczky, Robert

doi:10.1007/s00702-017-1810-z

2018

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Title:: Fluid biomarker agreement and interrelation in dementia due to Alzheimer's disease.
Document type:: Journal Article; Article
Author(s):: Alexopoulos, Panagiotis; Roesler, Jennifer; Werle, Lukas; Thierjung, Nathalie; Lentzari, Iliana; Ortner, Marion; Grimmer, Timo; Laskaris, Nikolaos; Politis, Antonios; Gourzis, Philippos; Kurz, Alexander; Perneczky, Robert
Abstract:: The cerebrospinal fluid (CSF) levels of ?-amyloid 42, total tau, and phosphorylated tau 181 are supposed to be all continuously abnormal in dementia due to Alzheimer's disease (AD), being the most advanced disease stage. The aim of the present study, which included a monocentric and a multicentric sample (N = 119 and 178, respectively), was to investigate the degree of CSF biomarker agreement and interrelation in AD dementia. Based on previously published cut-off values, biomarker values were categorized as positive or negative for AD (dichotomization strategy) and as either positive, negative, or borderline (trichotomization strategy). The statistical analyses relied on distance correlation analysis and kappa (k) statistics. Poor agreement (k < 0.4) and low interrelations between the studied biomarkers were detected in all cases with the exception of the interrelation between the markers total tau and phosphorylated tau 181, especially in the monocentric sample. Interestingly, lower interrelation and agreement degrees were observed in carriers of the Apolipoprotein E ?4 allele compared to non-carriers. The clinical phenotype currently referred to as "AD dementia" is characterized by an inhomogeneous CSF biomarker profile, possibly mirroring the complex genesis of AD-typical dementia symptoms and pointing to the necessity of shedding more light on the hypothesis of biomarker stability over time in symptomatic AD.
Journal title abbreviation:: J Neural Transm
Year:: 2018
Journal volume:: 125
Journal issue:: 2
Pages contribution:: 193-201
Language:: eng
Fulltext / DOI:: doi:10.1007/s00702-017-1810-z
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/29143217
Print-ISSN:: 0300-9564
TUM Institution:: Klinik und Poliklinik für Psychiatrie und Psychotherapie
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Psychiatrie und Psychotherapie (Prof. Priller)2018