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Titel:

Cerebrospinal Fluid BACE1 Activity and sA?PP? as Biomarker Candidates of Alzheimer's Disease.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Article
Autor(en):
Alexopoulos, Panagiotis; Thierjung, Nathalie; Grimmer, Timo; Ortner, Marion; Economou, Polychronis; Assimakopoulos, Konstantinos; Gourzis, Philippos; Politis, Antonios; Perneczky, Robert
Abstract:
The utility of ?-site amyloid-? precursor protein (A?PP) cleaving enzyme 1 (BACE1) activity and soluble A?PP ? (sA?PP?) levels in cerebrospinal fluid (CSF) in detecting Alzheimer's disease (AD) is still elusive.BACE1 activity and sA?PP? concentration were measured in patients with AD dementia (n = 56) and mild cognitive impairment (MCI) due to AD (n = 76) with abnormal routine AD CSF markers, in patients with MCI with normal CSF markers (n = 39), and in controls without preclinical AD (n = 48)....     »
Zeitschriftentitel:
Dement Geriatr Cogn Disord
Jahr:
2018
Band / Volume:
45
Heft / Issue:
3-4
Seitenangaben Beitrag:
152-161
Sprache:
eng
Volltext / DOI:
doi:10.1159/000488481
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29788013
Print-ISSN:
1420-8008
TUM Einrichtung:
Klinik und Poliklinik für Psychiatrie und Psychotherapie
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