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Title:

Pharmacokinetics of cefuroxime in infants and neonates undergoing cardiac surgery.

Document type:
Journal Article
Author(s):
Gertler, Ralph; Gruber, Michael; Wiesner, Gunther; Grassin-Delyle, Stanislas; Urien, Saïk; Tassani-Prell, Peter; Martin, Klaus
Abstract:
Very little data exist regarding the effect of cardiopulmonary bypass (CPB) on cefuroxime (CXM) pharmacokinetics in children less than one year of age.50 mg kg CXM i.v. after induction were followed by 75 mg kg into the CPB circuit. In 42 patients undergoing cardiac surgery, 15-20 samples were obtained between 5 and 360 min after the first dose. Total CXM concentrations were measured by high-performance liquid chromatography and a pharmacokinetic/pharmacodynamic (PK/PD) modelling was performed.U...     »
Journal title abbreviation:
Br J Clin Pharmacol
Year:
2018
Journal volume:
84
Journal issue:
9
Pages contribution:
2020-2028
Fulltext / DOI:
doi:10.1111/bcp.13632
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29761538
Print-ISSN:
0306-5251
TUM Institution:
Fachgebiet Kardioanästhesie (Prof. Tassani-Prell)
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