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Titel:

Pharmacokinetics of cefuroxime in infants and neonates undergoing cardiac surgery.

Dokumenttyp:
Journal Article
Autor(en):
Gertler, Ralph; Gruber, Michael; Wiesner, Gunther; Grassin-Delyle, Stanislas; Urien, Saïk; Tassani-Prell, Peter; Martin, Klaus
Abstract:
Very little data exist regarding the effect of cardiopulmonary bypass (CPB) on cefuroxime (CXM) pharmacokinetics in children less than one year of age.50 mg kg CXM i.v. after induction were followed by 75 mg kg into the CPB circuit. In 42 patients undergoing cardiac surgery, 15-20 samples were obtained between 5 and 360 min after the first dose. Total CXM concentrations were measured by high-performance liquid chromatography and a pharmacokinetic/pharmacodynamic (PK/PD) modelling was performed.U...     »
Zeitschriftentitel:
Br J Clin Pharmacol
Jahr:
2018
Band / Volume:
84
Heft / Issue:
9
Seitenangaben Beitrag:
2020-2028
Volltext / DOI:
doi:10.1111/bcp.13632
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29761538
Print-ISSN:
0306-5251
TUM Einrichtung:
Fachgebiet Kardioanästhesie (Prof. Tassani-Prell)
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