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Title:

Suppression of Arrhythmia by Enhancing Mitochondrial Ca2+ Uptake in Catecholaminergic Ventricular Tachycardia Models.

Document type:
Journal Article
Author(s):
Schweitzer, Maria K; Wilting, Fabiola; Sedej, Simon; Dreizehnter, Lisa; Dupper, Nathan J; Tian, Qinghai; Moretti, Alessandra; My, Ilaria; Kwon, Ohyun; Priori, Silvia G; Laugwitz, Karl-Ludwig; Storch, Ursula; Lipp, Peter; Breit, Andreas; Mederos Y Schnitzler, Michael; Gudermann, Thomas; Schredelseker, Johann
Abstract:
Cardiovascular disease-related deaths frequently arise from arrhythmias, but treatment options are limited due to perilous side effects of commonly used antiarrhythmic drugs. Cardiac rhythmicity strongly depends on cardiomyocyte Ca2+ handling and prevalent cardiac diseases are causally associated with perturbations in intracellular Ca2+ handling. Therefore, intracellular Ca2+ transporters are lead candidate structures for novel and safer antiarrhythmic therapies. Mitochondria and mitochondrial C...     »
Journal title abbreviation:
JACC Basic Transl Sci
Year:
2017
Journal volume:
2
Journal issue:
6
Pages contribution:
737-747
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jacbts.2017.06.008
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29354781
Print-ISSN:
2452-302X
TUM Institution:
Arbeitsgruppe Tissue Engineering und Regenerative Medizin; I. Medizinische Klinik und Poliklinik (Kardiologie)
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