Longitudinal progression of fetal short-term variation and average acceleration and deceleration capacity after antenatal maternal betamethasone application.

Weyrich, Joy; Setter, Anna; Müller, Alexander; Schmidt, Georg; Brambs, Christine E; Ortiz, Javier U; Lobmaier, Silvia M

doi:10.1016/j.ejogrb.2017.03.025

2017

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Document type:: Journal Article; Article
Author(s):: Weyrich, Joy; Setter, Anna; Müller, Alexander; Schmidt, Georg; Brambs, Christine E; Ortiz, Javier U; Lobmaier, Silvia M
Title:: Longitudinal progression of fetal short-term variation and average acceleration and deceleration capacity after antenatal maternal betamethasone application.
Abstract:: To analyze the effect of maternal betamethasone given for fetal lung maturation on fetal short-term variation (STV) and average acceleration and deceleration capacity (AAC/ADC). Both of these factors are calculated by phase-rectified signal averaging (PRSA) and represent new parameters to assess the fetal autonomic nervous system.A longitudinal prospective study including 26 pregnant women at risk for preterm delivery was performed. Two injections of 12mg betamethasone were administered intramuscularly at a 24h interval for lung maturation. Cardiotocography recordings were performed at defined time intervals: day 0 (before the first injection) and days 1, 2, 4 after the first corticosteroid administration. AAC/ADC and STV were calculated.An increase of all parameters (STV, AAC and ADC) was documented between day 0 and day 1. Between day 1 and day 2, all three indices were significantly reduced (p<0.05). STV declined by 19.8%, AAC by 10.1% and ADC by 14.8%. A normalization of these values was seen after 96h.Similar to STV, AAC/ADC shows significant changes after maternal betamethasone administration. The corticosteroid-induced transient decrease of the levels needs to be taken into account in the assessment of the fetal status to avoid misinterpretation of these parameters.
Journal title abbreviation:: Eur J Obstet Gynecol Reprod Biol
Year:: 2017
Journal volume:: 212
Pages contribution:: 85-90
Language:: eng
Fulltext / DOI:: doi:10.1016/j.ejogrb.2017.03.025
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/28342395
Print-ISSN:: 0301-2115
TUM Institution:: Frauenklinik und Poliklinik; I. Medizinische Klinik und Poliklinik (Kardiologie)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Frauenheilkunde (Prof. Kiechle)2017

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Innere Medizin I, Kardiologie (Prof. Laugwitz)2017