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Titel:

Thymosin 4 Improves Differentiation and Vascularization of EHTs.

Dokumenttyp:
Journal Article
Autor(en):
Ziegler, Tilman; Hinkel, Rabea; Stöhr, Andrea; Eschenhagen, Thomas; Laugwitz, Karl-Ludwig; le Noble, Ferdinand; David, Robert; Hansen, Arne; Kupatt, Christian
Abstract:
Induced pluripotent stem cells (iPSC) constitute a powerful tool to study cardiac physiology and represents a promising treatment strategy to tackle cardiac disease. However, iPSCs remain relatively immature after differentiation. Additionally, engineered heart tissue (EHT) has been investigated as a therapy option in preclinical disease models with promising results, although their vascularization and functionality leave room for improvement. Thymosin 4 (T4) has been shown to promote the differ...     »
Zeitschriftentitel:
Stem Cells Int
Jahr:
2017
Band / Volume:
2017
Seitenangaben Beitrag:
6848271
Sprache:
eng
Volltext / DOI:
doi:10.1155/2017/6848271
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28191018
Print-ISSN:
1687-966X
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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