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Title:

Preferential degradation of cognitive networks differentiates Alzheimer's disease from ageing.

Document type:
Journal Article; Article
Author(s):
Chhatwal, Jasmeer P; Schultz, Aaron P; Johnson, Keith A; Hedden, Trey; Jaimes, Sehily; Benzinger, Tammie L S; Jack, Clifford; Ances, Beau M; Ringman, John M; Marcus, Daniel S; Ghetti, Bernardino; Farlow, Martin R; Danek, Adrian; Levin, Johannes; Yakushev, Igor; Laske, Christoph; Koeppe, Robert A; Galasko, Douglas R; Xiong, Chengjie; Masters, Colin L; Schofield, Peter R; Kinnunen, Kirsi M; Salloway, Stephen; Martins, Ralph N; McDade, Eric; Cairns, Nigel J; Buckles, Virginia D; Morris, John C; Bat...     »
Abstract:
Converging evidence from structural, metabolic and functional connectivity MRI suggests that neurodegenerative diseases, such as Alzheimer's disease, target specific neural networks. However, age-related network changes commonly co-occur with neuropathological cascades, limiting efforts to disentangle disease-specific alterations in network function from those associated with normal ageing. Here we elucidate the differential effects of ageing and Alzheimer's disease pathology through simultaneou...     »
Journal title abbreviation:
Brain
Year:
2018
Journal volume:
141
Journal issue:
5
Pages contribution:
1486-1500
Fulltext / DOI:
doi:10.1093/brain/awy053
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29522171
Print-ISSN:
0006-8950
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin
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