User: Guest  Login
More Searchfields
Simple search
Title:

Preclinical evaluation of PSMA expression in response to androgen receptor blockade for theranostics in prostate cancer.

Document type:
Journal Article
Author(s):
Lückerath, Katharina; Wei, Liu; Fendler, Wolfgang P; Evans-Axelsson, Susan; Stuparu, Andreea D; Slavik, Roger; Mona, Christine E; Calais, Jeremie; Rettig, Matthew; Reiter, Robert E; Herrmann, Ken; Radu, Caius G; Czernin, Johannes; Eiber, Matthias
Abstract:
BACKGROUND: Prostate-specific membrane antigen (PSMA)-directed radioligand therapy (RLT) is a promising yet not curative approach in castration-resistant (CR) prostate cancer (PC). Rational combination therapies may improve treatment efficacy. Here, we explored the effect of androgen receptor blockade (ARB) on PSMA expression visualized by PET and its potential additive effect when combined with 177Lu-PSMA RLT in a mouse model of prostate cancer. METHODS: Mice bearing human CRPC (C4-2 cells) xen...     »
Journal title abbreviation:
EJNMMI Res
Year:
2018
Journal volume:
8
Journal issue:
1
Fulltext / DOI:
doi:10.1186/s13550-018-0451-z
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30374743
Print-ISSN:
2191-219X
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin
 BibTeX