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Titel:

Preclinical evaluation of PSMA expression in response to androgen receptor blockade for theranostics in prostate cancer.

Dokumenttyp:
Journal Article
Autor(en):
Lückerath, Katharina; Wei, Liu; Fendler, Wolfgang P; Evans-Axelsson, Susan; Stuparu, Andreea D; Slavik, Roger; Mona, Christine E; Calais, Jeremie; Rettig, Matthew; Reiter, Robert E; Herrmann, Ken; Radu, Caius G; Czernin, Johannes; Eiber, Matthias
Abstract:
BACKGROUND: Prostate-specific membrane antigen (PSMA)-directed radioligand therapy (RLT) is a promising yet not curative approach in castration-resistant (CR) prostate cancer (PC). Rational combination therapies may improve treatment efficacy. Here, we explored the effect of androgen receptor blockade (ARB) on PSMA expression visualized by PET and its potential additive effect when combined with 177Lu-PSMA RLT in a mouse model of prostate cancer. METHODS: Mice bearing human CRPC (C4-2 cells) xen...     »
Zeitschriftentitel:
EJNMMI Res
Jahr:
2018
Band / Volume:
8
Heft / Issue:
1
Volltext / DOI:
doi:10.1186/s13550-018-0451-z
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30374743
Print-ISSN:
2191-219X
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin
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