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Titel:

CXCR4-directed theranostics in oncology and inflammation

Dokumenttyp:
Review
Autor(en):
Kircher, Malte; Herhaus, Peter; Schottelius, Margret; Buck, Andreas K.; Werner, Rudolf A.; Wester, Hans-Juergen; Keller, Ulrich; Lapa, Constantin
Abstract:
Given its prominent role in inflammation and cancer biology, the C-X-C motif chemokine receptor 4 (CXCR4) has gained a lot of attention in the recent years. This review gives a short overview of the physiology and pathology of chemokines and chemokine receptors and then focuses on the current experience of targeting CXCR4, using radiolabeled receptor ligands suitable for positron emission tomography (PET) imaging, in both hematologic and solid malignancy as well as in inflammatory conditions. Ad...     »
Zeitschriftentitel:
Ann Nucl Med
Jahr:
2018
Band / Volume:
32
Heft / Issue:
8
Seitenangaben Beitrag:
503-511
Volltext / DOI:
doi:10.1007/s12149-018-1290-8
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30105558
Print-ISSN:
0914-7187
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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