Login
- Dokumenttyp:
- Journal Article; Multicenter Study; Article
- Autor(en):
- Ndrepepa, Gjin; Xhepa, Erion; Colleran, Roisin; Braun, Siegmund; Cassese, Salvatore; Fusaro, Massimiliano; Laugwitz, Karl-Ludwig; Kastrati, Adnan
- Titel:
- Gamma-glutamyl transferase and atrial fibrillation in patients with coronary artery disease.
- Abstract:
- The association between gamma-glutamyl transferase (GGT) and atrial fibrillation (AF) in patients with coronary artery disease (CAD) is uncertain.This study included 5501 consecutive patients with CAD, all of whom had baseline GGT measurements available. The primary endpoint was presence of AF.Overall 809 patients (14.7%) had AF on hospital admission. Patients with AF had significantly higher GGT activity compared with patients in sinus rhythm (median [25th-75th percentile]: 52.0 [32.9-96.0] U/L versus 34.8 [23.8-55.9] U/L, P<0.001). The prevalence of AF increased from 8.6% of patients in the first GGT decile to 30.3% of patients in the tenth decile (P<0.001). After multivariable adjustment, GGT activity remained independently associated with the probability of the presence of AF (adjusted adds ratio=1.66, 95% confidence interval 1.53-1.81, P<0.001 for each standard deviation increment in the GGT logarithmic scale). GGT predicted the probability of AF with an area under the receiver operating characteristic (ROC) curve of 0.6496, 95% confidence interval 0.6287 to 0.6705, P<0.001 indicating moderate strength to discriminate between patients with and without AF.In patients with CAD, elevated GGT activity is independently associated with the presence of AF. GGT may be a circulating marker of the risk for AF.
- Zeitschriftentitel:
- Clin Chim Acta
- Jahr:
- 2017
- Band / Volume:
- 465
- Seitenangaben Beitrag:
- 17-21
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1016/j.cca.2016.12.003
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/27939920
- Print-ISSN:
- 0009-8981
- TUM Einrichtung:
- I. Medizinische Klinik und Poliklinik (Kardiologie); Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
BibTeX