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Title:

Dose-dependent effects of peroxisome proliferator-activated receptors ?/? agonist on systemic inflammation after haemorrhagic shock.

Document type:
Journal Article
Author(s):
Yin, Luxu; Busch, Daniel; Qiao, Zhi; Van Griensven, Martijn; Teuben, Michel; Hildebrand, Frank; Pape, Hans-Christoph; Pfeifer, Roman
Abstract:
PPAR?/? agonists are known to modulate the systemic inflammatory response after sepsis. In this study, inflammation modulation effects of PPAR?/? are investigated using the selective PPAR?/? agonist (GW0742) in a model of haemorrhagic shock (HS)-induced sterile systemic inflammation.Blood pressure-controlled (35±5mmHg) HS was performed in C57/BL6 mice for 90min. Low-dose GW0742 (0.03mg/kg/BW) and high-dose GW0742 (0.3mg/kg/BW) were then administered at the beginning of resuscitation. Mice were s...     »
Journal title abbreviation:
Cytokine
Year:
2018
Journal volume:
103
Pages contribution:
127-132
Fulltext / DOI:
doi:10.1016/j.cyto.2017.09.021
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28969938
Print-ISSN:
1043-4666
TUM Institution:
Klinik und Poliklinik für Unfallchirurgie
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