Benutzer: Gast  Login
Titel:

The posttraumatic activation of CD4+ T regulatory cells is modulated by TNFR2- and TLR4-dependent pathways, but not by IL-10.

Dokumenttyp:
Journal Article
Autor(en):
Bock, Matthias; Bergmann, Christian B; Jung, Sonja; Kalbitz, Miriam; Relja, Borna; Huber-Wagner, Stefan; Biberthaler, Peter; Van Griensven, Martijn; Hanschen, Marc
Abstract:
Platelets modulate the immune system following injury by interacting with CD4+ T regulatory cells (CD4+ Tregs). The underlying mechanisms remain unsolved. We hypothesize paracrine interactions via Tumor necrosis factor-alpha (TNF?)-, Toll like receptor-4 (TLR4)-, and Interleukin-10 (IL-10). In the murine burn injury model, CD4+ Treg activation pathways were selectively addressed using TNFR2-, TLR4- and IL-10-deficient mice. The CD4+ Treg signalling molecule PKC-? was analyzed using phospho-flow...     »
Zeitschriftentitel:
Cell Immunol
Jahr:
2018
Band / Volume:
331
Seitenangaben Beitrag:
137-145
Volltext / DOI:
doi:10.1016/j.cellimm.2018.06.009
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29954581
Print-ISSN:
0008-8749
TUM Einrichtung:
Klinik und Poliklinik für Unfallchirurgie
 BibTeX