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Title:

Hypoglossal nerve stimulation on sleep and level of alertness in OSA: A preliminary study.

Document type:
Journal Article
Author(s):
Philip, Pierre; Heiser, Clemens; Bioulac, Stéphanie; Altena, Ellemarije; Penchet, Guillame; Cuny, Emmanuel; Hofauer, Benedikt; Monteyrol, Pierre-Jean; Micoulaud-Franchi, Jean-Arthur
Abstract:
OBJECTIVES: To quantify the effect of hypoglossal nerve stimulation (HNS), a novel therapy for patients with obstructive sleep apnea, on objective level of alertness (measured with Maintenance of Wakefulness Test [MWT] values) and nocturnal sleep architecture. METHODS: Ten male patients (mean age 52.0 ± 9.4 years; mean body mass index 28.8 ± 3.3 kg/m2) noncompliant to continuous positive airway pressure received HNS (Inspire therapy) and were prospectively evaluated at baseline and 6 months after HNS therapy. Polysomnographic parameters (sleep breathing and sleep architecture) and objective level of alertness (MWT) were measured. RESULTS: The mean preimplantation apnea-hypopnea index of 46.7/h ± 12.2/h was reduced to 14.5/h ± 8.9/h at 6 months postimplantation (p < 0.001). The mean MWT latency improved from 25.0 ± 12.8 minutes at baseline to 36.8 ± 7.0 minutes after 6 months of treatment (p = 0.004). A reduction of N1% (11.8 ± 10.6 vs 4.2 ± 1.9, p = 0.04) was observed. The reduction in the duration of wake after sleep onset (WASO) was 71.4 ± 32.4 minutes vs 53.4 ± 13.5 minutes (p = 0.06) but was not significant. MWT latencies at 6 months were negatively correlated with the intensity of stimulation (r = -0.63, p = 0.05). Intensity of stimulation was positively correlated with WASO (r = 0.76, p = 0.01). CONCLUSION: HNS improved the objective level of alertness and changed nocturnal sleep architecture. The level of neural stimulation determines the amount of nocturnal WASO and the level of objective level of alertness.
Journal title abbreviation:
Neurology
Year:
2018
Journal volume:
91
Journal issue:
7
Pages contribution:
e615-e619
Fulltext / DOI:
doi:10.1212/WNL.0000000000006001
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30021916
Print-ISSN:
0028-3878
TUM Institution:
Hals-Nasen-Ohrenklinik und Poliklinik
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