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Title:

CXCR4: A New Player in an Old Scene?

Document type:
Journal Article; Review
Author(s):
Knopf, Andreas; Fritsche, Marie Kristin; Li, Yin
Abstract:
Transmembrane C-X-C chemokine receptor 4 (CXCR4) and its ligand C-X-C motif chemokine 12 (CXCL12) came into focus in many solid cancers, allowing a more fundamental diagnostic and therapeutic approach by modulating the immune response against cancer cells. CXCR4 and CXCL12 mediate cell proliferation, migration, and metastatic outgrowth in head and neck squamous cell carcinoma (HNSCC) and are strongly associated with cancer recurrence and patient survival. Despite recent advances in molecular ima...     »
Journal title abbreviation:
ORL J Otorhinolaryngol Relat Spec
Year:
2017
Journal volume:
79
Journal issue:
1-2
Pages contribution:
34-42
Language:
eng
Fulltext / DOI:
doi:10.1159/000455706
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28231592
Print-ISSN:
0301-1569
TUM Institution:
Hals-Nasen-Ohrenklinik und Poliklinik
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