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Title:

KMT2B Is Selectively Required for Neuronal Transdifferentiation, and Its Loss Exposes Dystonia Candidate Genes.

Document type:
Article
Author(s):
Barbagiovanni, Giulia; Germain, Pierre-Luc; Zech, Michael; Atashpaz, Sina; Lo Riso, Pietro; D'Antonio-Chronowska, Agnieszka; Tenderini, Erika; Caiazzo, Massimiliano; Boesch, Sylvia; Jech, Robert; Haslinger, Bernhard; Broccoli, Vania; Stewart, Adrian Francis; Winkelmann, Juliane; Testa, Giuseppe
Abstract:
Transdifferentiation of fibroblasts into induced neuronal cells (iNs) by the neuron-specific transcription factors Brn2, Myt1l, and Ascl1 is a paradigmatic example of inter-lineage conversion across epigenetically distant cells. Despite tremendous progress regarding the transcriptional hierarchy underlying transdifferentiation, the enablers of the concomitant epigenome resetting remain to be elucidated. Here, we investigated the role of KMT2A and KMT2B, two histone H3 lysine 4 methylases with ca...     »
Journal title abbreviation:
Cell Rep
Year:
2018
Journal volume:
25
Journal issue:
4
Pages contribution:
988-1001
Fulltext / DOI:
doi:10.1016/j.celrep.2018.09.067
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30355503
Print-ISSN:
2211-1247
TUM Institution:
Institut für Humangenetik; Lehrstuhl für Neurogenetik (Prof. Winkelmann); Neurologische Klinik und Poliklinik
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