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- Titel:
Prognostic Value of Tumor Volume in Glioblastoma Patients: Size Also Matters for Patients with Incomplete Resection.
- Dokumenttyp:
- Journal Article
- Autor(en):
- Bette, Stefanie; Barz, Melanie; Wiestler, Benedikt; Huber, Thomas; Gerhardt, Julia; Buchmann, Niels; E Combs, Stephanie; Schmidt-Graf, Friederike; Delbridge, Claire; Zimmer, Claus; S Kirschke, Jan; Meyer, Bernhard; Ryang, Yu-Mi; Ringel, Florian; Gempt, Jens
- Abstract:
- BACKGROUND: Incomplete resection of glioblastoma is discussed controversially in the era of combined radiochemotherapy. OBJECTIVE: The aim of this study was to analyze the benefit of subtotal tumor resection for glioblastoma patients as this was recently questioned in the era of radiochemotherapy. METHODS: Overall, 209 patients undergoing surgery for newly diagnosed WHO grade IV gliomas were retrospectively analyzed, and pre- and postoperative tumor volumes were manually segmented (cm3). Survival analyses were performed, including prognostic factors such as age, Karnofsky performance score (KPS), O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status, and adjuvant treatment regimen. RESULTS: Pre- and postoperative tumor volume is significantly associated with pre- and postoperative KPS, as well as age (p < 0.001). Postoperative tumor volume remained a significant prognostic factor in a multivariate analysis, independent of other prognostic factors (hazard ratio 1.0365, 95% confidence interval 1.0235-1.0497, p < 0.001). CONCLUSIONS: In the era of molecularly-driven radiochemotherapy, glioblastoma surgery remains a major prognostic factor. Even in situations in which a gross total resection cannot be achieved, maximum safe reduction of tumor burden should be attempted.
- Zeitschriftentitel:
- Ann Surg Oncol
- Jahr:
- 2018
- Band / Volume:
- 25
- Heft / Issue:
- 2
- Seitenangaben Beitrag:
- 558-564
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1245/s10434-017-6253-0
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/29159745
- Print-ISSN:
- 1068-9265
- TUM Einrichtung:
- Fachgebiet Neuroradiologie (Prof. Zimmer); Klinik und Poliklinik für RadioOnkologie und Strahlentherapie; Neurochirurgische Klinik und Poliklinik; Neurologische Klinik und Poliklinik
BibTeX
Vorkommen:
- mediaTUM GesamtbestandEinrichtungenSchools TUM School of Medicine and HealthDepartmentsClinical MedicineKlinik und Poliklinik für RadioOnkologie und Strahlentherapie (Prof. Combs)2018
- mediaTUM GesamtbestandEinrichtungenSchools TUM School of Medicine and HealthDepartmentsClinical MedicineInstitut für Diagnostische und Interventionelle Radiologie (Prof. Makowski)Abteilung für Diagnostische und Interventionelle Neuroradiologie (Prof. Zimmer)Professur für Neuroradiologie (Prof. Zimmer)2018