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Titel:

Non-invasive Chamber-Specific Identification of Cardiomyocytes in Differentiating Pluripotent Stem Cells.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Brauchle, Eva; Knopf, Anne; Bauer, Hannah; Shen, Nian; Linder, Sandra; Monaghan, Michael G; Ellwanger, Kornelia; Layland, Shannon L; Brucker, Sara Y; Nsair, Ali; Schenke-Layland, Katja
Abstract:
One major obstacle to the application of stem cell-derived cardiomyocytes (CMs) for disease modeling and clinical therapies is the inability to identify the developmental stage of these cells without the need for genetic manipulation or utilization of exogenous markers. In this study, we demonstrate that Raman microspectroscopy can non-invasively identify embryonic stem cell (ESC)-derived chamber-specific CMs and monitor cell maturation. Using this marker-free approach, Raman peaks were identifi...     »
Zeitschriftentitel:
Stem Cell Reports
Jahr:
2016
Band / Volume:
6
Heft / Issue:
2
Seitenangaben Beitrag:
188-99
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.stemcr.2015.12.007
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26777059
TUM Einrichtung:
Hals-Nasen-Ohrenklinik und Poliklinik
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