Determinants of elevated carbohydrate antigen 125 in patients with severe symptomatic aortic valve stenosis referred for transcatheter aortic valve implantation.

Rheude, Tobias; Pellegrini, Costanza; Reinhard, Wibke; Trenkwalder, Teresa; Koenig, Wolfgang; Mayr, N Patrick; Joner, Michael; Núñez, Julio; Holdenrieder, Stefan; Schunkert, Heribert; Kastrati, Adnan; Hengstenberg, Christian; Husser, Oliver

doi:10.1080/1354750X.2018.1423706

2018

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Title:: Determinants of elevated carbohydrate antigen 125 in patients with severe symptomatic aortic valve stenosis referred for transcatheter aortic valve implantation.
Document type:: Journal Article; Article
Author(s):: Rheude, Tobias; Pellegrini, Costanza; Reinhard, Wibke; Trenkwalder, Teresa; Koenig, Wolfgang; Mayr, N Patrick; Joner, Michael; Núñez, Julio; Holdenrieder, Stefan; Schunkert, Heribert; Kastrati, Adnan; Hengstenberg, Christian; Husser, Oliver
Abstract:: Elevated carbohydrate antigen 125 (CA125) predicts adverse outcome after transcatheter aortic valve implantation (TAVI). While known underlying pathophysiological mechanisms of elevated CA125 include serosal effusions and inflammatory stimuli, clinical determinants associated with elevated CA125 in patients referred for TAVI remain unknown. Therefore, we investigated clinical, laboratory and echocardiographic determinants of elevated CA125 in patients with severe aortic valve stenosis referred for TAVI.This study includes 650 patients with severe aortic stenosis referred for TAVI. Baseline CA125 was determined by an immunoassay and dichotomized (elevated versus normal) based on the manufacturer cutoff value (>35 U/mL).CA125 elevation was present in 28% (181/650). Patients with elevated CA125 had an overall worse clinical profile and were more symptomatic with a higher rate of NYHA class III/IV (80% versus 58%; p < 0.001). In a multivariate analysis, independent predictors of elevated CA125 were New York Heart Association (NYHA) class, baseline hemoglobin, C-reactive protein (CRP), left ventricular ejection fraction and severe tricuspid regurgitation.Elevated CA125 levels in patients referred for TAVI summarize a subset of patients with an overall worse clinical profile who are more symptomatic.
Journal title abbreviation:: Biomarkers
Year:: 2018
Journal volume:: 23
Journal issue:: 3
Pages contribution:: 299-304
Language:: eng
Fulltext / DOI:: doi:10.1080/1354750X.2018.1423706
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/29297708
Print-ISSN:: 1354-750X
TUM Institution:: Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!); Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (DHM) (Prof. Schunkert)2018

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Institut für Laboratoriumsmedizin (DHM) (Prof. Holdenrieder)2018