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Title:

Repeated mutKRAS ctDNA measurements represent a novel and promising tool for early response prediction and therapy monitoring in advanced pancreatic cancer.

Document type:
Journal Article; Article
Author(s):
Krüger, S; Heinemann, V; Ross, C; Diehl, F; Nagel, D; Ormanns, S; Liebmann, S; Prinz-Bravin, I; Westphalen, C B; Haas, M; Jung, A; Kirchner, T; von Bergwelt-Baildon, M; Boeck, S; Holdenrieder, S
Abstract:
Background: The presence of mutated KRAS (mutKRAS ctDNA) in plasma samples has been consistently shown to be a negative prognostic indicator in pancreatic cancer (PC). Only small pilot studies have evaluated the value of serial mutKRAS ctDNA-measurements in PC. Patients and methods: The aim of the present study was to explore the potential of repeated mutKRAS ctDNA measurements for response prediction and therapy monitoring in advanced PC patients. We used the BEAMing technology to determine lev...     »
Journal title abbreviation:
Ann Oncol
Year:
2018
Journal volume:
29
Journal issue:
12
Pages contribution:
2348-2355
Fulltext / DOI:
doi:10.1093/annonc/mdy417
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30346475
Print-ISSN:
0923-7534
TUM Institution:
Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!)
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