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Titel:

Improved sensitivity for detection of breast cancer by combination of miR-34a and tumor markers CA 15-3 or CEA.

Dokumenttyp:
Journal Article
Autor(en):
Zaleski, Martin; Kobilay, Makbule; Schroeder, Lars; Debald, Manuel; Semaan, Alexander; Hettwer, Karina; Uhlig, Steffen; Kuhn, Walther; Hartmann, Gunther; Holdenrieder, Stefan
Abstract:
Background: MicroRNAs biomarkers have shown value for diagnosis and prognosis of various cancers. Combination with established tumor markers has rarely been done. Results: Breast cancer patients had significantly higher serum RNA loads (AUC 0.665), lower miR-34a (AUC 0.772), higher CEA and CA 15-3 levels (AUCs 0.717 and 0.721) than healthy controls. miR-34a correlated with tumor stage and hormone receptor status. There was no significant difference between groups for all other miRNAs. Combinatio...     »
Zeitschriftentitel:
Oncotarget
Jahr:
2018
Band / Volume:
9
Heft / Issue:
32
Seitenangaben Beitrag:
22523-22536
Volltext / DOI:
doi:10.18632/oncotarget.25077
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29854296
TUM Einrichtung:
Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!)
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