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Titel:

Pharmacokinetics of tranexamic acid in neonates and infants undergoing cardiac surgery.

Dokumenttyp:
Clinical Trial; Journal Article; Article
Autor(en):
Gertler, Ralph; Gruber, Michael; Grassin-Delyle, Stanislas; Urien, Saïk; Martin, Klaus; Tassani-Prell, Peter; Braun, Siegmund; Burg, Simon; Wiesner, Gunther
Abstract:
Tranexamic acid (TXA) continues to be one of the antifibrinolytics of choice during paediatric cardiac surgery. However, in infants less than 1 year of age, the optimal dosing based on pharmacokinetic (PK) considerations is still under discussion.Forty-three children less than 1 year of age were enrolled, of whom 37 required the use of cardiopulmonary bypass (CPB) and six were operated on without CPB. Administration of 50 mg kg TXA intravenously at the induction of anaesthesia was followed by 50...     »
Zeitschriftentitel:
Br J Clin Pharmacol
Jahr:
2017
Band / Volume:
83
Heft / Issue:
8
Seitenangaben Beitrag:
1745-1757
Sprache:
eng
Volltext / DOI:
doi:10.1111/bcp.13274
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28245519
Print-ISSN:
0306-5251
TUM Einrichtung:
Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!)
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