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Titel:

Selection of an Anticalin® against the membrane form of Hsp70 via bacterial surface display and its theranostic application in tumour models.

Dokumenttyp:
Journal Article
Autor(en):
Friedrich, Lars; Kornberger, Petra; Mendler, Claudia T; Multhoff, Gabriele; Schwaiger, Markus; Skerra, Arne
Abstract:
We describe the selection of Anticalins against a common tumour surface antigen, human Hsp70, using functional display on live Escherichia coli cells as fusion with a truncated EspP autotransporter. While found intracellularly in normal cells, Hsp70 is frequently exposed in a membrane-bound state on the surface of tumour cells and, even more pronounced, in metastases or after radiochemotherapy. Employing a recombinant Hsp70 fragment comprising residues 383-548 as the target, Anticalins were sele...     »
Zeitschriftentitel:
Biol Chem
Jahr:
2018
Band / Volume:
399
Heft / Issue:
3
Seitenangaben Beitrag:
235-252
Sprache:
eng
Volltext / DOI:
doi:10.1515/hsz-2017-0207
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29140786
Print-ISSN:
1431-6730
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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