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Titel:

DNA damage interactions on both nanometer and micrometer scale determine overall cellular damage.

Dokumenttyp:
Journal Article
Autor(en):
Friedrich, Thomas; Ilicic, Katarina; Greubel, Christoph; Girst, Stefanie; Reindl, Judith; Sammer, Matthias; Schwarz, Benjamin; Siebenwirth, Christian; Walsh, Dietrich W M; Schmid, Thomas E; Scholz, Michael; Dollinger, Günther
Abstract:
DNA double strand breaks (DSB) play a pivotal role for cellular damage, which is a hazard encountered in toxicology and radiation protection, but also exploited e.g. in eradicating tumors in radiation therapy. It is still debated whether and in how far clustering of such DNA lesions leads to an enhanced severity of induced damage. Here we investigate - using focused spots of ionizing radiation as damaging agent - the spatial extension of DNA lesion patterns causing cell inactivation. We find tha...     »
Zeitschriftentitel:
Sci Rep
Jahr:
2018
Band / Volume:
8
Heft / Issue:
1
Seitenangaben Beitrag:
16063
Sprache:
eng
Volltext / DOI:
doi:10.1038/s41598-018-34323-9
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30375461
Print-ISSN:
2045-2322
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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