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Title:

A PRDX1-p38α heterodimer amplifies MET-driven invasion of IDH-wildtype and IDH-mutant gliomas.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Wirthschaft, Peter; Bode, Julia; Simon, Anika E M; Hoffmann, Elisa; van Laack, Rebecca; Krüwel, Thomas; Dietrich, Fabio; Bucher, Delia; Hahn, Artur; Sahm, Felix; Breckwoldt, Michael O; Kurz, Felix T; Hielscher, Thomas; Fischer, Bernd; Dross, Nicolas; Ruiz de Almodovar, Carmen; von Deimling, Andreas; Herold-Mende, Christel; Plass, Christoph; Boulant, Steeve; Wiestler, Benedikt; Reifenberger, Guido; Lichter, Peter; Wick, Wolfgang; Tews, Björn
Abstract:
The Peroxiredoxin 1 (PRDX1) gene maps to chromosome arm 1p and is hemizygously deleted and epigenetically silenced in isocitrate dehydrogenase 1 or 2 (IDH)-mutant and 1p/19q-codeleted oligodendroglial tumors. In contrast, IDH-wildtype astrocytic gliomas including glioblastomas mostly lack epigenetic silencing and express PRDX1 protein. In our study, we investigated how PRDX1 contributes to the infiltrative growth of IDH-wildtype gliomas. Focusing on p38α-dependent pathways, we analyzed clinical...     »
Journal title abbreviation:
Int J Cancer
Year:
2018
Journal volume:
143
Journal issue:
5
Pages contribution:
1176-1187
Fulltext / DOI:
doi:10.1002/ijc.31404
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29582423
Print-ISSN:
0020-7136
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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