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Titel:

Inhibition of CD95/CD95L (FAS/FASLG) Signaling with APG101 Prevents Invasion and Enhances Radiation Therapy for Glioblastoma.

Dokumenttyp:
Journal Article
Autor(en):
Blaes, Jonas; Thomé, Carina M; Pfenning, Philipp-Niclas; Rübmann, Petra; Sahm, Felix; Wick, Antje; Bunse, Theresa; Schmenger, Torsten; Sykora, Jaromir; von Deimling, Andreas; Wiestler, Benedikt; Merz, Christian; Jugold, Manfred; Haberkorn, Uwe; Abdollahi, Amir; Debus, Jürgen; Gieffers, Christian; Kunz, Claudia; Bendszus, Martin; Kluge, Michael; Platten, Michael; Fricke, Harald; Wick, Wolfgang; Lemke, Dieter
Abstract:
CD95 (Fas/APO-1), a death receptor family member, activity has been linked to tumorigenicity in multiple cancers, including glioblastoma multiforme (GBM). A phase II clinical trial on relapsed glioblastoma patients demonstrated that targeted inhibition of CD95 signaling via the CD95 ligand (CD95L) binding and neutralizing Fc-fusion protein APG101 (asunercept) prolonged patient survival. Although CD95 signaling may be relevant for multiple aspects of tumor growth, the mechanism of action of APG10...     »
Zeitschriftentitel:
Mol Cancer Res
Jahr:
2018
Band / Volume:
16
Heft / Issue:
5
Seitenangaben Beitrag:
767-776
Volltext / DOI:
doi:10.1158/1541-7786.MCR-17-0563
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29453321
Print-ISSN:
1541-7786
TUM Einrichtung:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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