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Title:

The Lack of WIP Binding to Actin Results in Impaired B Cell Migration and Altered Humoral Immune Responses.

Document type:
Article; Journal Article
Author(s):
Keppler, Selina Jessica; Burbage, Marianne; Gasparrini, Francesca; Hartjes, Lara; Aggarwal, Shweta; Massaad, Michel J; Geha, Raif S; Bruckbauer, Andreas; Batista, Facundo D
Abstract:
Wiskott-Aldrich syndrome protein (WASp) is a main cytoskeletal regulator in B cells. WASp-interacting protein (WIP) binds to and stabilizes WASp but also interacts with actin. Using mice with a mutated actin binding domain of WIP (WIPΔABD), we here investigated the role of WIP binding to actin during B cell activation. We found an altered differentiation of WIPΔABD B cells and diminished antibody affinity maturation after immunization. Mechanistically, WIPΔABD B cells showed impaired B cell rece...     »
Journal title abbreviation:
Cell Rep
Year:
2018
Journal volume:
24
Journal issue:
3
Pages contribution:
619-629
Fulltext / DOI:
doi:10.1016/j.celrep.2018.06.051
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30021160
Print-ISSN:
2211-1247
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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