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Title:

The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Kasper, Lydia; König, Annika; Koenig, Paul-Albert; Gresnigt, Mark S; Westman, Johannes; Drummond, Rebecca A; Lionakis, Michail S; Groß, Olaf; Ruland, Jürgen; Naglik, Julian R; Hube, Bernhard
Abstract:
Clearance of invading microbes requires phagocytes of the innate immune system. However, successful pathogens have evolved sophisticated strategies to evade immune killing. The opportunistic human fungal pathogen Candida albicans is efficiently phagocytosed by macrophages, but causes inflammasome activation, host cytolysis, and escapes after hypha formation. Previous studies suggest that macrophage lysis by C. albicans results from early inflammasome-dependent cell death (pyroptosis), late damag...     »
Journal title abbreviation:
Nat Commun
Year:
2018
Journal volume:
9
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-018-06607-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30323213
Print-ISSN:
2041-1723
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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