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Title:

Upregulation of UBE2Q1 via gene copy number gain in hepatocellular carcinoma promotes cancer progression through β-catenin-EGFR-PI3K-Akt-mTOR signaling pathway.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Zhang, Bin; Deng, Chao; Wang, Lei; Zhou, Fan; Zhang, Shu; Kang, Wei; Zhan, Ping; Chen, Juan; Shen, Shanshan; Guo, Huimin; Zhang, Ming; Wang, Yi; Zhang, Feng; Zhang, Wei; Xiao, Jiangqiang; Kong, Bo; Friess, Helmut; Zhuge, Yuzheng; Yan, Hongli; Zou, Xiaoping
Abstract:
Hepatocellular carcinoma (HCC) is the most common type of liver cancer and represents a highly malignant tumor with a poor prognosis. Therapeutic modalities for HCC are limited and generally ineffective. UBE2Q1 is a putative E2 ubiquitin conjugating enzyme, and has been shown to be overexpressed in various types of cancers including HCC. How UBE2Q1 contributes to hepatocarcinogenesis remains unknown. Here, we show that UBE2Q1 is up-regulated in HCC cell lines and in a subset of human HCC tissues...     »
Journal title abbreviation:
Mol Carcinog
Year:
2018
Journal volume:
57
Journal issue:
2
Pages contribution:
201-215
Fulltext / DOI:
doi:10.1002/mc.22747
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29027712
Print-ISSN:
0899-1987
TUM Institution:
Chirurgische Klinik und Poliklinik
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