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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Brænne, Ingrid; Kleinecke, Mariana; Reiz, Benedikt; Graf, Elisabeth; Strom, Tim; Wieland, Thomas; Fischer, Marcus; Kessler, Thorsten; Hengstenberg, Christian; Meitinger, Thomas; Erdmann, Jeanette; Schunkert, Heribert
Titel:
Systematic analysis of variants related to familial hypercholesterolemia in families with premature myocardial infarction.
Abstract:
Familial hypercholesterolemia (FH) is an oligogenic disorder characterized by markedly elevated low-density lipoprotein cholesterol (LDLC) levels. Variants in four genes have been reported to cause the classical autosomal-dominant form of the disease. FH is largely under-diagnosed in European countries. As FH increases the risk for coronary artery disease (CAD) and myocardial infarction (MI), it might be specifically overlooked in the large number of such patients. Here, we systematically examin...     »
Zeitschriftentitel:
Eur J Hum Genet
Jahr:
2016
Band / Volume:
24
Heft / Issue:
2
Seitenangaben Beitrag:
191-7
Sprache:
eng
Volltext / DOI:
doi:10.1038/ejhg.2015.100
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26036859
Print-ISSN:
1018-4813
TUM Einrichtung:
Institut für Humangenetik; Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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