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Title:

MEIS1 variant as a determinant of autonomic imbalance in Restless Legs Syndrome.

Document type:
journal article
Author(s):
Thireau, Jérôme; Farah, Charlotte; Molinari, Nicolas; Bouilloux, Fabrice; Torreilles, Lucas; Winkelmann, Juliane; Scholz, Sabine; Richard, Sylvain; Dauvilliers, Yves; Marmigère, Frédéric
Abstract:
Restless Legs Syndrome (RLS) is a genetically complex neurological disorder in which overlapping genetic risk factors may contribute to the diversity and heterogeneity of the symptoms. The main goal of the study was to investigate, through analysis of heart rate variability (HRV), whether in RLS patients the MEIS1 polymorphism at risk influences the sympathovagal regulation in different sleep stages. Sixty-four RLS patients with periodic leg movement index above 15 per hour, and 38 controls unde...     »
Journal title abbreviation:
Sci Rep
Year:
2017
Journal volume:
7
Pages contribution:
46620
Language:
eng
Fulltext / DOI:
doi:10.1038/srep46620
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28425489
TUM Institution:
Klinik und Poliklinik für Neurologie
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